Longevity
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ChromAgeNet reads ageing in the nuclei of blood stem cells
A neural network told young from aged mouse blood stem cells with 77% accuracy from 3D images of their chromatin, and scored candidate rejuvenating drugs.
A speech clock reads biological ageing from 2,928 voices
A Science Advances study links the gap between speech-predicted and actual age to brain atrophy, DNA-methylation clocks, p-tau217 and social adversity.
Transplanted hearts take on the biological age of their recipients
A Brigham and Women's preprint finds donor hearts adopt the recipient's biological age in mice and humans, while the recipient's own aging markers stay unchanged.
Loyal's third dog-lifespan drug clears the FDA efficacy bar
The FDA accepted the efficacy section for LOY-003, Loyal's daily pill for large dogs, so all three of the company's lifespan drugs have now cleared it.
Twelve aging rate indicators proposed to speed anti-aging trials
A Frontiers in Science lead article argues a single measurement could show whether a drug has put an animal into a slow-aging state.
A chromatin protein keeps ancient viruses quiet in microglia
DAXX declines with age in the brain immune cells, letting dormant retrotransposons reactivate and driving DNA damage, senescence and neuroinflammation.
The human hippocampus remodels itself between 50 and 75
A Science study finds embryonic microglia giving way to blood-derived immune cells, blood-brain-barrier populations thinning, and 3D genome architecture eroding in midlife.
A sulfur switch decides when ageing brain proteins clump
Oxidation pushes synapsin 1 and G3BP2 into condensates as mice age, while hydrogen-sulfide persulfidation keeps them fluid — and ergothioneine reversed the effect in cells.
BioAge doses first patient in oral NLRP3 trial for macular edema
QUELL-DME will test whether a once-daily pill can hold vision in diabetic macular edema, including in patients who get no eye injections at all.
Moonwalk raised $70M to shrink fat with RNAi, not appetite
A Series B co-led by Alpha Wave and YK Bioventures, with Eli Lilly participating, funds an siRNA aimed at adipose tissue toward first-in-human trials in late 2027.
Genflow's SIRT6 gene therapy met its endpoint in old beagles
The SLAB trial in 24 dogs over ten years old hit its primary endpoint of reduced biological age on the GRIM methylation clock, Genflow said on 8 September 2026.
Six aging clocks read lower biological age in an AI drug trial
Insilico Medicine reported in Nature Biotechnology on 7 September 2026 that all six proteomic clocks applied to 42 patients on rentosertib pointed the same way.
Switching off growth hormone at midlife extended mouse lifespan
Ohio University researchers ablated the growth hormone receptor in 12-month-old mice and reported longer life in both sexes in Aging Cell, September 2026.
XPRIZE Healthspan names ten finalists
Ten teams advanced in the $101 million, seven-year competition, among them Minicircle, which will run a placebo-controlled gene therapy trial on ageing.
Semaglutide started late in life extends lifespan in female mice
A Nature paper reports median lifespan rising from 742 to 834 days in female mice first dosed at 20 months, with several measures beating matched calorie restriction.
A gut bacterium and its metabolite extend healthspan in aged mice
Nature Aging reports that Bifidobacterium pseudocatenulatum declines with age in humans, and that it and its metabolite 5-AVAB reduce multiorgan inflammation in old mice.
Sex-specific aging clocks put men and women on different timetables
A cohort of more than 100,000 Chinese adults and 172 routine clinical measures produced separate aging clocks that diverge in midlife and reconverge later.
Eight bat genomes tie longevity to antiviral and cancer defences
UC Berkeley researchers report in Nature that the longest-lived Myotis bats carry extra copies of antiviral genes, and that their damaged cells die rather than attempt repair.
A nanogel turns support cells into neurons in Alzheimer's mice
Nano-ERASER crosses the blood-brain barrier and degrades PTBP1, reprogramming astrocytes into neurons; treated mice rebuilt nests and solved water mazes.
An injected muscle graft that exercises itself, tested in mice
Chinese Academy of Sciences researchers report myografts that self-assemble under the skin, contract on their own, and improve bone, liver and cognitive measures.
A biological age score arrives as a $29 add-on at 2,000 US labs
Humanity Biological Age went live on questhealth.com on 25 August 2026, converting an existing Quest blood panel into a single age number without a second draw.
A youth-associated blood protein restored debris clearance in old brains
Mount Sinai researchers report in Nature Communications that TIMP2 governs microglial state, and that giving it to aged mice restored their capacity to clear debris.
A three-drug mix extended old mice lifespan by 42 percent
Berkeley researchers combined dichloroacetate, metformin and a low dose of navitoclax, and aged mice lived a median 1,002 days against 815 for controls.
XPRIZE names 20 healthspan finalists and pays out $10 million
Ten of the twenty finalist teams in the $101 million XPRIZE Healthspan received $1 million each at a Salt Lake City ceremony on 11 August 2026.
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